I as am working on the quest framework at the moment I thought I would go ahead and highlight how quests will work.
Since the rest of the game is skill based quests will be as well. Players will see quests based on their skill sets and can follow those quests, increasing experience and skills in the process. If at some point in time you decide to train up an unused skill you can then start taking quests following that skill line. Some quests will take you into the same areas and essentially same paths as others but the rewards will be tailored to the skill required to take the quest.
The quests update is still a few weeks out but I am going to go ahead and push up some bug fixes tonight and if I have time I will add some more areas.